Author

Howard M. Bomze

Duke UniversityORCID 0000-0002-2243-4286Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 4 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Assay:proteomics· 2 Approach:statistical model· 2

Frequent Co-Authors

Romain CartoniiD· 3 shared Liam S.C. LewisiD· 2 shared Nikolai P. SkibaiD· 2 shared Sidney M. GospeiD· 2 shared Vadim Y. ArshavskyiD· 2 shared Ying HaoiD· 2 shared Adrián Martí PastoriD· 1 shared Almudena del Rio Martin· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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3 shared papersNeuroscience

Romain CartoniORCID

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4 papers

Recent·Most cited

Pharmacological Depletion of Retinal Mononuclear Phagocytes is Neuroprotective in a Mouse Model of Mitochondrial Optic Neuropathy

Avital Lily Okrent Smolar, Rahul Viswanath, Howard M. Bomze, Hao Ying, Sandra S. Stinnett, Sidney M. Gospe

This study shows that pharmacological depletion of retinal mononuclear phagocytes with pexidartinib, combined with hypoxia, completely protects retinal ganglion cells in a mouse model of mitochondrial optic neuropathy.

Investigative Ophthalmology & Visual Science · Feb 2, 2026Peer-reviewedNeuroscience

Neuronal compartmentalization results in impoverished axonal mitochondria

Adrián Martí Pastor, Liam S.C. Lewis, Stephan Müller, Pedro Guedes-Dias, Lorena Olifiers, Polina Pelkonen, Almudena del Rio Martin, Caroline Fecher, Nikolai P. Skiba, Ying Hao, Antoneta Gavoci, Laura Trovò, Mehmet Akif Aktas, Hariharan Murali Mahadevan, Angelika Bettina Harbauer, , Thomas Misgeld

The paper uses proteomics to compare mitochondrial diversity in somatodendritic and axonal compartments across neurons, finding axonal mitochondria are 'impoverished' with reduced mtDNA expression and impaired oxidative phosphorylation.

bioRxiv · Oct 27, 2025 · PreprintNeuroscience

Compartmental Differences in the Retinal Ganglion Cell Mitochondrial Proteome

Liam S.C. Lewis, Nikolai P. Skiba, Ying Hao, Howard M. Bomze, Vadim Y. Arshavsky, Romain Cartoni, Sidney M. Gospe

The paper identifies compartment-specific mitochondrial proteins in retinal ganglion cells using mass spectrometry and immunofluorescence validation.

bioRxiv · May 7, 2024 · PreprintCell Biology

Local Accumulation of Axonal Mitochondria in the Optic Nerve Glial Lamina Precedes Myelination

Samantha J. Wilkison, Cora L. Bright, Ricardo Gomes Vancini, Daniel J. Song, Howard M. Bomze, Romain Cartoni

The paper shows that mitochondrial accumulation in the optic nerve glial lamina occurs in larger axons before myelination, challenging the belief that myelination drives this accumulation.

Frontiers in Neuroanatomy · May 20, 2021Peer-reviewedNeuroscience