Reactive astrocytes associated with prion disease impair the blood brain barrier
Rajesh Kushwaha, Yue Li, Natallia Makarava, Narayan Prasad Pandit, Kara Molesworth, Konstantin G. Birukov, Ilia V. Baskakov
This study shows that reactive astrocytes in prion disease impair BBB integrity through proinflammatory factors like IL-6, leading to early BBB breakdown.
Neurobiology of Disease · Aug 18, 2023Peer-reviewedNeuroscience