Narayan Prasad Pandit

This study investigates the role of astrocytic Stat3 in prion disease, finding it modulates astrocyte reactivity but has limited impact on disease progression, with context-dependent effects.

This study shows that Galectin-3 promotes microglial uptake of PrPSc, slowing prion disease progression by enhancing phagocytic sequestration of prions.

This study shows that P2Y12 receptor knockout increases microglia-neuron body-to-body interactions and accelerates prion disease progression in mice.

The paper shows that in prion diseases, microglia engulf viable neurons during late preclinical stages, independent of the CD11b pathway, and this occurs across multiple brain regions and sCJD subtypes.

This study investigates prion strain adaptation to a new host using synthetic prions, finding that adaptation involves multiple stages including changes in PrPSc properties and microglia interaction.

This study shows that reactive astrocytes in prion disease impair BBB integrity through proinflammatory factors like IL-6, leading to early BBB breakdown.

This study shows that Alzheimer's disease-associated β-Amyloid does not protect against HSV-1 brain infection in 5XFAD mice.