Deletion of genes encoding PU.1 and Spi-B leads to B cell acute lymphoblastic leukemia associated with driver mutations in Janus Kinases
Carolina R. Batista, Michelle Lim, Anne-Sophie Laramée, Faisal Abu-Sardanah, Li S. Xu, Rajon Hossain, Rodney P. DeKoter
This study shows that deletion of PU.1 and Spi-B in mice leads to B-ALL with JAK mutations as secondary drivers.
bioRxiv · Apr 2, 2018 · PreprintCancer Biology