Hedgehog signalling regulates patterning of the murine and human dentitions through Gas1 co-receptor function
Maisa Seppala, Béatrice Thivichon‐Prince, Guilherme Machado Xavier, Nina Shaffie, Indiya Sangani, Anahid A. Birjandi, Joshua Rooney, Jane N. S. Lau, Rajveer Dhalivar, Ornella Rossi, Adeel Riaz, Daniel Stonehouse‐Smith, Yiran Wang, Laurent Viriot, Martyn T. Cobourne
This study shows that Gas1 regulates tooth number and morphology in mice and humans by modulating Hedgehog and Wnt signaling during development.
bioRxiv · Nov 6, 2020 · PreprintDevelopmental Biology