Chromosome-arm-specific telomere length governs dual modes of structural genome evolution in IDH-mutant astrocytoma
Maryam Jehangir, Kristen L. Drucker, Ayşe Gökçe Keşküş, T. Rhyker Ranallo-Benavidez, Orléna Benamozig, Thomas Kollmeyer, Terry C. Burns, Caterina Giannini, Benjamin R. Kipp, Stephen James Murphy, Amber R. Bridgeman, Jesse R. Walsh, Ramanath Majumdar, Daniel H. Lachance, Jeanette E. Eckel‐Passow, , Floris P Barthel
This study uses long-read sequencing to show that telomere length differences between chromosome arms influence structural genome changes in IDH-mutant astrocytomas.
bioRxiv · Apr 23, 2026 · PreprintCancer Biology