Cryo-EM structure of Pol κ-DNA-PCNA holoenzyme and implications for polymerase switching in DNA lesion bypass
Claudia Lancey, Muhammad Tehseen, Masateru Takahashi, Mohamed A Sobhy, Timothy J Ragan, Ramon Crehuet, Samir M Hamdan, Alfredo De Biasio
The paper determines Cryo-EM structures of Pol κ-DNA-PCNA and Pol δ-DNA-PCNA complexes to elucidate the mechanism of polymerase switching during DNA lesion bypass.
bioRxiv · Jul 10, 2020 · PreprintBiochemistry