Human cytomegalovirus antagonizes SMC5/6 driven genome silencing via UL35 instituted proteasomal degradation of SLF2
Francesco Montagner, Myriam Scherer, Cora Stegmann, Friedrich Hahn, Claudia Ploil, Christina Sandra Einsiedler, Takahiro Maeki, Ramya Ramani, Nicole Andrée-Busch, Melanie M. Brinkmann, Thomas Stamminger
This study identifies UL35 as a viral protein that degrades SLF2, preventing SMC5/6 from silencing HCMV genomes.
bioRxiv · May 27, 2026 · PreprintMicrobiology