The impediment to replication at tRNA genes in S. cerevisiae does not require tRNA transcription, and is facilitated by topoisomerases and Rad18-dependent repair pathways
The study shows that tRNA gene replication fork pausing in yeast is not due to transcription but involves topoisomerases and Rad18 repair, even when transcription is blocked.
bioRxiv · Jan 29, 2020 · PreprintMolecular Biology