Bistability to Quad-stability: Emergence of Hybrid Phenotypes & Enhanced Spatio-temporal Plasticity in Presence of Host-Circuit Coupling
Ranu Kundu, Priya Chakraborty, Sohini Guin, Shyam Sundar Poriah, Sayantari Ghosh
The paper investigates how host-circuit coupling and resource competition drive spatiotemporal plasticity and multistability in genetic circuits, with implications for cancer progression.
bioRxiv · Feb 15, 2026 · PreprintCancer Biology