Nanobodies targeting hnRNPA2/B1 and tau
Azady Pirhanov, Cristian Rodriguez, Fatemeh Tashakori-Asfestani, Raven Gonsoulin, Rayne Santiago, Katarnut Tobunluepop, Emmanuella Erhunmwunsee, Sambhavi Puri, Monika Arbaciauskaite, Wu He, Benjamin L. Wolozin, Yong Ku Cho
The paper develops nanobodies targeting hnRNPA2/B1 and tau, showing they colocalize with targets and can reduce protein levels when fused to ubiquitin ligase domains.
bioRxiv · Nov 21, 2025 · PreprintBioengineering