Sambhavi Puri

The paper develops nanobodies targeting hnRNPA2/B1 and tau, showing they colocalize with targets and can reduce protein levels when fused to ubiquitin ligase domains.

The paper shows that loss of age-related m6A RNA methylation in Alzheimer's disease brains is linked to GABAergic dysfunction and synaptic issues.

This study shows GSK3β phosphorylation drives tau aggregation into Alzheimer's-like amyloid strains through enhanced phase separation.

This study shows TIA1 regulates divergent inflammatory responses in microglia and macrophages, reducing brain inflammation and tau pathology while increasing peripheral inflammation.

The paper uses proximity labeling to study the dynamic SQSTM1 protein network and shows that aggregated tau alters its interactions with stress-associated proteins.

The paper identifies circRNAs associated with Alzheimer's disease and related dementias through transcriptome analysis and validates their expression in neuronal precursor cells exposed to oligomeric tau.