HIV-1 Assembly is Assisted by IRSp53 Through an Interaction that Extends Gag Conformation
Curt Waltmann, Peggy Mérida, Puja Banerjee, Karolina Buresova, Chloé Poussineau, Julien Burlaud‐Gaillard, Raviteja Gurram, Jeriann R. Beiter, Cyril Favard, Delphine M. Muriaux, Gregory A. Voth
The paper shows that IRSp53 assists HIV-1 assembly by interacting with Gag and extending its conformation, which is validated through simulations and experiments.
bioRxiv · Oct 6, 2026 · PreprintMolecular Biology