Delphine M. Muriaux

Real-time single-molecule imaging in zebrafish embryos uncovers non-canonical translation

This study uses real-time single-molecule imaging in zebrafish embryos to reveal non-canonical translation mechanisms of bmp2b mRNA.

HIV-1 Assembly is Assisted by IRSp53 Through an Interaction that Extends Gag Conformation

The paper shows that IRSp53 assists HIV-1 assembly by interacting with Gag and extending its conformation, which is validated through simulations and experiments.

SARS-CoV-2 nucleocapsid protein engages with viral RNA and ERGIC lipids to drive viral core assembly

This study shows that SARS-CoV-2 nucleocapsid protein interacts with viral RNA and ERGIC lipids to drive viral core assembly through lipid clustering and RNP stabilization.

Comprehensive Analysis of Neutrophil Immunomodulatory Properties and FcR Dynamics in Health and HIV-1 Infection and Therapy

The paper examines neutrophil immunomodulatory properties and FcR dynamics in HIV-1 infection and therapy, finding altered cytokine production and FcR expression in PLWH.

Nucleus softens during herpesvirus infection

This study shows that the nucleus softens during herpesvirus infection due to reduced outward forces and low biomolecular density in the viral replication compartment.

Human pluripotent stem cell-derived bronchial airway organoids provide insights into differential innate immune and long-term responses to SARS-CoV-2 infection in healthy and COPD.

This study uses human iPSC-derived bronchial organoids to show SARS-CoV-2 causes prolonged infection, cilia destruction, and differential innate immune responses in healthy and COPD models.

The multifunction Coxiella effector Vice stimulates macropinocytosis and interferes with the ESCRT machinery

This study identifies the Coxiella effector Vice as a protein that manipulates host cell lipid composition and cellular pathways to form the Coxiella-containing vacuole.

Validation of Flavivirus Infectious Clones Carrying Fluorescent Markers for Antiviral Drug Screening and Replication Studies

The paper validates infectious clones of flaviviruses with fluorescent markers to enable antiviral drug screening and replication studies.

Biochemistry-informed design selects potent siRNAs against SARS-CoV-2

This paper designs potent siRNAs against SARS-CoV-2 using biochemistry-informed computational methods, achieving high antiviral activity and variant coverage.