Pharmacology & ToxicologybioRxivPreprint
Striatal M4 Receptors Mediate M4 PAM Antipsychotic-like Efficacy Independently of Normalizing Striatal Dopamine Release
Daniel G Joyner, Curran M. Johnston, Yumin Choi…·Daniel J. Foster
This study shows that M4 receptor PAMs have antipsychotic-like effects through dorsal striatal postsynaptic mechanisms, independent of changes in dopamine release.
DOI 10.64898/2026.10.26.761976