Complex effects of kinase localization revealed by compartment-specific regulation of protein kinase A activity
Rebecca LaCroix, Benjamin Lin, Tae-Yun Kang, Andre Levchenko
The paper shows that PKA-R translocation to the plasma membrane can both enhance and inhibit kinase activity depending on concentration, affecting cell migration directionality.
eLife · Feb 10, 2022Peer-reviewedSystems Biology