Regulation of Leucine-Rich Repeat Kinase 2 by inflammation and IL-4
Dina Dikovskaya, Rebecca Pemberton, Matthew Taylor, Anna Tasegian, Purbasha Bhattacharya, Karolina Zeneviciute, Esther M. Sammler, Andrew J.M. Howden, Dario R. Alessi, Mahima Swamy
This study investigates how inflammation and IL-4 regulate LRRK2 expression and activity in immune cells, revealing cell-specific effects and the role of the LRRK2-R1441C mutation.
EMBO Reports · May 20, 2025Peer-reviewedImmunology