Andrew J.M. Howden

Profiling peripheral immune cells in Parkinsons disease: A Scoping Review

This review synthesizes findings on peripheral immune cell changes in Parkinson's disease, identifying common immune signatures and methodological inconsistencies across studies.

Single cell proteomic analysis defines discrete neutrophil functional states in human glioblastoma

The paper uses single cell proteomic analysis to identify distinct functional states of neutrophils in human glioblastoma, revealing clusters with pathogenic and anti-tumorigenic properties not detectable by scRNA-seq.

Regulation of Leucine-Rich Repeat Kinase 2 by inflammation and IL-4

This study investigates how inflammation and IL-4 regulate LRRK2 expression and activity in immune cells, revealing cell-specific effects and the role of the LRRK2-R1441C mutation.

A proteogenomic tool uncovers protein markers for human microglial states

The paper introduces a proteomic tool to identify protein markers for human microglial states and validates their utility in purification and differentiation.

Autophagy repression by antigen and cytokines shapes mitochondrial, migration and effector machinery in CD8 T cells.

This study shows antigen and cytokines repress autophagy in CD8 T cells, shaping mitochondrial function, migration, and effector machinery through differential proteome pruning.

Synaptic Signatures and Disease Vulnerabilities of Layer 5 Pyramidal Neurons

The paper identifies distinct synaptic protein signatures and disease vulnerabilities in L5 IT and PT neurons, with autism risk genes enriched in L5 IT neurons.

A proteomic map of B cell activation and its shaping by mTORC1, MYC and iron

This study maps the proteomic changes in B cells during activation and shows how mTORC1, MYC, and iron regulate protein production and growth.

Lipopolysaccharide stimulates dynamic changes in B cell metabolism to promote proliferation

This study shows that LPS induces metabolic changes in B cells, including amino acid uptake and cholesterol metabolism, which are essential for proliferation.

Deep proteomic analysis of human microglia and model systems reveal fundamental biological differences of in vitro and ex vivo cells

The paper compares proteomic profiles of human and mouse microglia from different sources, revealing significant differences between in vitro and ex vivo cultures.

Astrocyte-Oligodendrocyte interaction regulates central nervous system regeneration

The paper shows that astrocyte-oligodendrocyte interaction is critical for remyelination and identifies a drug strategy targeting this interaction to promote central nervous system regeneration.