Mycoplasma gallisepticum uses itaconate-associated mitochondrial inhibition to suppress host immunometabolism
Soren Z. Coulson, Reihane Eric, Chidambaram Ramanathan, Katherine M. Talbott, Francis E. Tillman, Anna A. Pérez‐Umphrey, Truc Chi T. Pham, Paul S. Simone, Brandt D. Pence, James Stephen Adelman, Yufeng Zhang
This study shows Mycoplasma gallisepticum suppresses host immune responses by inhibiting mitochondrial respiration via itaconate, while inducing local inflammation.
bioRxiv · Aug 18, 2026 · PreprintImmunology