Hierarchically ordered multi-timescale structural dynamics of the intrinsically disordered p53 transactivation domain
Dániel Szöllősi, Supriya Pratihar, Dwaipayan Mukhopadhyay, Ashok Kumar Rout, Govardhan Reddy, Niklas Ebersberger, Stefan Becker, Gábor Nagy, Sarah Rauscher, Donghan Lee, Reinhard Klement, Christian Griesinger, Helmut Grubmüller
The paper characterizes the multi-timescale structural dynamics of the p53 transactivation domain using NMR and simulations, revealing a hierarchical energy landscape.
bioRxiv · Aug 1, 2025 · PreprintBiophysics