Hemodynamics regulate spatiotemporal artery muscularization in the developing circle of Willis
Siyuan Cheng, Ivan Fan Xia, Renate Wanner, Javier Abello, Amber N. Stratman, Stefania Nicoli
This study shows that blood flow activates endothelial klf2a, which regulates VSMC differentiation on zebrafish brain arteries in a spatiotemporal manner.
eLife · Feb 2, 2024Peer-reviewedDevelopmental Biology