Amber N. Stratman

Role of U11/U12 minor spliceosome gene ZCRB1 in Ciliogenesis and WNT Signaling

This study shows that ZCRB1 is essential for U12 splicing, ciliogenesis, and WNT signaling, with loss-of-function effects observed in human cells and zebrafish.

The E3 Ubiquitin Ligase Trip12 attenuates Wnt9a/Fzd9b signaling during hematopoietic stem cell development

The paper identifies Trip12 as an E3 ubiquitin ligase that ubiquitinates Fzd9b, reducing its availability and Wnt9a/Fzd9b signaling in zebrafish hematopoietic stem cells.

Neutrophil TLR2 signaling promotes lipid accumulation and vascular plaque growth

This study shows that neutrophil TLR2 signaling promotes lipid uptake and storage, contributing to atherosclerotic plaque growth.

Mitochondrial iron transport via MFRN1 is required for erythroid cell cycle progression

The paper shows that mitochondrial iron transport via MFRN1 is essential for erythroid cell cycle progression and terminal differentiation.

VEGFA critically controls neurovascular invasion and chronic low back pain during intervertebral disc degeneration

This study shows that VEGFA drives neurovascular invasion in degenerating intervertebral discs and contributes to chronic low back pain, with its inhibition preventing pain behaviors.

FAM210B regulates Iron Homeostasis and Sex-Specific Responses in Stress Erythropoiesis

This study shows FAM210B regulates iron homeostasis and sex-specific responses in stress erythropoiesis, with defects in spleen size and blood cell counts in knockout mice.

Endothelial cell Piezo1 promotes vascular smooth muscle cell differentiation on large arteries

This study shows that endothelial Piezo1 regulates vascular smooth muscle cell differentiation in zebrafish and mice by modulating klf2a levels and flow force sensing.

Oncogenic KRAS Mutations Confer a Unique Mechanotransduction Response to Peristalsis in Colorectal Cancer Cells

This study shows that oncogenic KRAS mutations in colorectal cancer cells lead to a unique mechanotransduction response to peristalsis, increasing cancer stem cell enrichment and tumorigenicity.

CXCR3-CXCL11 signaling restricts angiogenesis and promotes pericyte recruitment

This study identifies CXCR3-CXCL11 signaling as a regulator of endothelial cell angiogenesis and pericyte recruitment during development.

Regulation of angiogenesis by endocytic trafficking mediated by cytoplasmic dynein 1 light intermediate chain 1

This study shows that LIC1 and RILPL1/2 restrict angiogenesis by promoting VEGFR2 degradation, and their disruption increases angiogenesis through enhanced Rab11-mediated recycling.

Profiling the endothelial translatome in vivo using 'AngioTag' zebrafish

The paper introduces a zebrafish transgenic line to profile endothelial cell translatomes in vivo, revealing novel genes and expression signatures across adult organs.

Hemodynamics regulate spatiotemporal artery muscularization in the developing circle of Willis

This study shows that blood flow activates endothelial klf2a, which regulates VSMC differentiation on zebrafish brain arteries in a spatiotemporal manner.

Identification of overlapping and distinct mural cell populations during early embryonic development

The paper identifies novel tagln-positive mural cell populations in zebrafish embryos using transgenic markers and reveals their developmental contributions.

In vivo dissection of Rhoa function in vascular development using zebrafish

This study investigates the in vivo roles of RHOA in vascular development and integrity using zebrafish models, finding that both gain- and loss-of-function lead to vascular dysfunction.