Structure and function of the human apoptotic scramblase Xkr4
Sayan Chakraborty, Zhang Feng, Sangyun Lee, Omar E. Alvarenga, Aniruddha Panda, Shuming Zhang, Renato Bruni, George Khelashvili, Kallol Gupta, Alessio Accardi
This study investigates the structure and function of human Xkr4, showing it scrambles lipids and adopts a novel conformation that promotes membrane thinning, essential for phosphatidylserine externalization.
Nature Communications · Aug 8, 2025Peer-reviewedBiophysics