Shuming Zhang

This study shows that chromatin buffers torsional stress during transcription by enabling Pol II to transcribe through nucleosomes more efficiently than on single-nucleosome substrates.

This study develops a high-resolution assay to show that the replisome, composed of helicase and DNA polymerase, is a powerful torsional motor that regulates DNA replication stalling and reactivation.

This study investigates the structure and function of human Xkr4, showing it scrambles lipids and adopts a novel conformation that promotes membrane thinning, essential for phosphatidylserine externalization.