Kinase-specific phosphorylation of tau outside the amyloid core encodes fibril fold selection
Reshma Ramesh, Sambhasan Banerjee, Madhu Babu Gajula Balija, Pijush Chakraborty, Christian Dienemann, Meytal Landau, Markus Zweckstetter
The paper shows that ERK2 phosphorylation of tau outside the amyloid core directs fibril formation into an Alzheimer's disease-like structure.
bioRxiv · Aug 4, 2026 · PreprintMolecular Biology