Christian Dienemann

The paper determines the cryo-EM structure of cytoplasmic Pol II and shows Gdown1 inhibits its transcriptional activity by blocking essential factor binding.

The paper shows that ERK2 phosphorylation of tau outside the amyloid core directs fibril formation into an Alzheimer's disease-like structure.

This study investigates the role of the +1 nucleosome in transcription initiation and the transition to elongation using in vitro experiments and cryo-EM structures.

This study reveals the molecular mechanisms of cap-snatching by influenza polymerase using cryo-EM structures of FluPol bound to Pol II and DSIF.

This study reveals a three-step mechanism of co-transcriptional H3K36 methylation by SETD2 through cryo-EM structures and functional analysis.

This paper shows that anle138b binds to a cavity in lipidic Aβ fibrils and reduces fibril formation by 75%, suggesting a potential therapeutic mechanism for Alzheimer's disease.

This study identifies two binding sites of the PET tracer MODAG-005 on lipidic α-synuclein fibrils, with the cavity site being more stable and selectively occupied under certain conditions.

This study reveals how ELF2, a pioneer transcription factor, remodels nucleosomes near transcription start sites by unwrapping DNA and exposing chromatin, facilitating transcription initiation.

The paper determines the structure of amyloid-β (Aβ40) fibrils bound to lipids using cryo-EM, showing lipid binding and potential relevance to Alzheimer's disease pathogenesis.

This study determines the structural basis of RNA polymerase II initiation at snRNA promoters using SNAPc, revealing its role in DNA opening and transcription initiation independent of TFIIE and TFIIH.

The paper presents six atomic structures of α-synuclein fibrils in the presence of phospholipids, revealing how phospholipids influence fibril morphology and lipid interactions.

This study compares α-synuclein fibril structures from Parkinson's disease and Multiple System Atrophy patients, showing differences in their quaternary arrangement and effects on oligodendroglial cells.

The paper determines the structure of the human Mediator-RNA polymerase II transcription pre-initiation complex using cryo-EM, revealing interactions and conformational changes involved in transcription initiation.

The paper reports a dimeric structure of SARS-CoV-2 RdRp and suggests it may facilitate template switching during transcription.

The paper determines the structure of the yeast RSC chromatin remodeller bound to a nucleosome, revealing mechanisms of nucleosome sliding and implications for human SWI/SNF complexes and cancer.

The paper determines the cryo-EM structure of the human core TFIIH-XPA-DNA complex, revealing how XPA and XPG switch TFIIH from a transcription factor to a DNA repair factor.