Mutators can increase both the rate of occurrence and specificity of nitrofurantoin resistance mutations
Riannah Kettlewell, Jessica H. Forsyth, Danna R. Gifford
This study shows that increased mutation rates in E. coli lead to more and more specific nitrofurantoin resistance mutations, raising concerns about the antibiotic's long-term effectiveness.
bioRxiv · Oct 7, 2024 · PreprintMicrobiology