Richard Allen

Burden of rare pathogenic variants suggests disrupted cytoskeletal organisation in the pathogenesis of pulmonary fibrosis

The paper identifies rare pathogenic variants associated with pulmonary fibrosis by analyzing whole genome sequencing data and linking them to cytoskeletal dysfunction.

Predicting the viability of archaic human hybrids using a mitochondrial proxy

The paper predicts the viability of archaic human hybrids using mitochondrial DNA divergence patterns to assess fertility differences between species pairs.

Efficient Generation and Selection of Virtual Populations in Quantitative Systems Pharmacology Models

The paper introduces a method to generate and select Virtual Populations from Virtual Patients in quantitative systems pharmacology models without weighting, improving model prediction confidence.