Dapeng Wang

The Biobank Rare Variant consortium powers the discovery of rare genetic associations through global collaboration

The paper establishes a global consortium to discover rare genetic associations by integrating data from multiple biobanks, identifying 514 gene-trait associations, many detectable only through cross-ancestry meta-analysis.

Prpf8N1531S homozygous mutant mouse embryos have multiple defects in cardiac development and show aberrant splicing of the cardiac transcription factor Tead1

This study identifies a critical role for Prpf8 in cardiac development through aberrant splicing of Tead1 and disrupted Notch signaling in Prpf8N1531S homozygous mutant mice.

The RNA splicing factor PRPF8 is required for left-right organiser cilia differentiation and determination of cardiac left-right asymmetry via regulation of Arl13b splicing

This study identifies PRPF8 as essential for left-right organiser cilia function and cardiac asymmetry by regulating ARL13B splicing in mice and zebrafish.

A 3D endometrium-on-a-chip reveals the role of conceptus-derived factors CAPG and PDI in conceptus-endometrial communication

This paper develops a 3D bovine endometrium-on-a-chip system to study conceptus-derived factors CAPG and PDI's effects on endometrial transcriptome and secretome.

Burden of rare pathogenic variants suggests disrupted cytoskeletal organisation in the pathogenesis of pulmonary fibrosis

The paper identifies rare pathogenic variants associated with pulmonary fibrosis by analyzing whole genome sequencing data and linking them to cytoskeletal dysfunction.

Association between mosaic loss of chromosome Y and pulmonary fibrosis susceptibility and severity

This study investigates the association between mosaic loss of chromosome Y (mLOY) and pulmonary fibrosis, finding mLOY correlates with age and telomere length but not disease severity, and suggests a potential link between telomere shortening and mLOY.

Biosensor capability of the endometrium is mediated in part, by altered miRNA cargo from conceptus-derived extracellular vesicles.

The paper investigates how endometrial biosensor capability is influenced by miRNA cargo in conceptus-derived extracellular vesicles during peri-implantation, showing differential miRNA effects on endometrial gene expression.

The embryo-derived protein PDI is highly conserved among placental mammals and alters the function of the endometrium in species with different implantation strategies.

The paper shows that PDI, a conserved protein, alters endometrial function in species with different implantation strategies by modifying transcriptomes and secretomes.

EFCAB4B (CRACR2A) genetic variants associated with COVID-19 fatality

The paper identifies three SNPs in EFCAB4B (CRACR2A) associated with increased risk of COVID-19 fatality through missense mutations affecting protein structure and function.

Endometrium-on-a-chip reveals the endometrial transcriptome, and protein content of secretome are altered by changes in circulating concentrations of insulin and glucose in vitro.

The paper uses an endometrium-on-a-chip system to show that changes in glucose and insulin concentrations alter the transcriptome and secretome of endometrial cells in vitro.

LncRNAs interacting with the translation machinery contribute to human neuronal differentiation.

The paper identifies lncRNAs that interact with the translation machinery during neuronal differentiation and shows some produce peptides that affect neurite length.