Author

Richard C. Brown

Centre for Human Genetics

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Research Focus:variant effect prediction· 2 Assay:ATAC-seq· 1 Approach:deep learning· 1 Assay:DNA methylation· 1 Organism:human· 1 Approach:machine learning (classical)· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

A. Marieke OudelaariD· 2 shared Damien J. DownesiD· 2 shared Gerton A. LunteriD· 2 shared Jelena M. TeleniusiD· 2 shared Jim R. HughesiD· 2 shared Matthew E. GosdeniD· 2 shared Ron SchweßingeriD· 2 shared Andrew John KingiD· 1 shared

Activity by Year

2020-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersGenomics

A. Marieke OudelaarORCID

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2 papers

Recent·Most cited

DeepC: Predicting chromatin interactions using megabase scaled deep neural networks and transfer learning.

Ron Schweßinger, Matthew E. Gosden, Damien J. Downes, Richard C. Brown, A. Marieke Oudelaar, Jelena M. Telenius, Yee Whye Teh, Gerton A. Lunter, Jim R. Hughes

DeepC predicts chromatin interactions from DNA sequence using deep learning and transfer learning, generalizing across cell types and resolutions.

Nature Methods · Oct 12, 2020Peer-reviewedGenomics

An integrated platform to systematically identify causal variants and genes for polygenic human traits.

Damien J. Downes, Ron Schweßinger, Stephanie Hill, Lea Nußbaum, Caroline Scott, Matthew E. Gosden, Priscila P. Hirschfeld, Jelena M. Telenius, Chris Q. Eijsbouts, Simon J. McGowan, Antony J. Cutler, Jon Kerry, Jessica L. Davies, Calliope Athena Dendrou, Jamie R. J. Inshaw, , Jim R. Hughes

The paper develops a platform combining ATAC-seq, DNaseI footprints, NG Capture-C, and machine learning to identify causal variants and genes for polygenic human traits.

bioRxiv · Jan 15, 2020 · PreprintGenetics