Author
University of Oxford
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
5 papers
Recent·Most cited
Nicholas T. Crump, Erica Ballabio, Laura Godfrey, Ross Thorne, Emmanouela Repapi, Jon Kerry, Marta Cecylia Tapia, Hua Peng, B. Christoffer Lagerholm, P. Filippakopoulos, James O. J. Davies, Thomas A. Milne
The paper shows BET inhibition reduces transcription but not enhancer-promoter contacts, suggesting these processes are separable.
Nature Communications · Jan 11, 2021Peer-reviewedMolecular Biology
A. Marieke Oudelaar, Robert A. Beagrie, Matthew E. Gosden, Sara De Ornellas, Emily Georgiades, Jon Kerry, Daniel Hidalgo, Joana Carrelha, Arun Shivalingam, Afaf Helmy El-Sagheer, Jelena M. Telenius, Tom P Brown, Veronica J. Buckle, Merav Socolovsky, Douglas R. Higgs, Jim R. Hughes
The paper studies chromatin architecture changes during mouse erythroid differentiation using Tiled-C and shows enhancer-promoter interactions form during differentiation, not before gene expression.
Nature Communications · Jun 1, 2020Peer-reviewedGenomics
Damien J. Downes, Matthew E. Gosden, Jelena M. Telenius, Stephanie J. Carpenter, Lea Nußbaum, Sara De Ornellas, Martin J. Sergeant, Chris Q. Eijsbouts, Ron Schweßinger, Jon Kerry, Nigel A. Roberts, Arun Shivalingam, Afaf Helmy El-Sagheer, A. Marieke Oudelaar, Tom P Brown, , Jim R. Hughes
The paper introduces a new method, NuTi Capture-C, that improves high-resolution chromosome conformation capture by reducing noise and increasing sequencing content, enabling reproducible genome-wide interaction profiles.
bioRxiv · Mar 2, 2020 · PreprintGenomics
Jelena M. Telenius, Damien J. Downes, Martin J. Sergeant, A. Marieke Oudelaar, Simon J. McGowan, Jon Kerry, Lars L.P. Hanssen, Ron Schweßinger, Chris Q. Eijsbouts, James O. J. Davies, Stephen Taylor, Jim R. Hughes
CaptureCompendium provides software tools to simplify the design, analysis, and visualization of 3C experiments, addressing the need for specialized bioinformatics skills in genome folding studies.
bioRxiv · Feb 17, 2020 · PreprintBioinformatics
Damien J. Downes, Ron Schweßinger, Stephanie Hill, Lea Nußbaum, Caroline Scott, Matthew E. Gosden, Priscila P. Hirschfeld, Jelena M. Telenius, Chris Q. Eijsbouts, Simon J. McGowan, Antony J. Cutler, Jon Kerry, Jessica L. Davies, Calliope Athena Dendrou, Jamie R. J. Inshaw, , Jim R. Hughes
The paper develops a platform combining ATAC-seq, DNaseI footprints, NG Capture-C, and machine learning to identify causal variants and genes for polygenic human traits.
bioRxiv · Jan 15, 2020 · PreprintGenetics