TL1A/DR3 signaling regulates the generation of pathogenic Th9 cells in experimental inflammatory bowel disease
Paola Menghini, Ludovica F. Buttó, Adrian Gomez-Nguyen, Natalia A. Aladyshkina, Kristine-Ann G. Buela, Abdullah Ösme, Ricky Chan, Hannah L. Wargo, Stefania De Santis, Giorgos Bamias, Theresa T. Pizarro, Fabio Cominelli
This study shows that DR3 signaling promotes Th9 cell pathogenicity in CD-like ileitis by enhancing pro-inflammatory signatures and reducing anti-inflammatory responses.
Gastroenterology · May 15, 2025Peer-reviewedImmunology