Author

Paola Menghini

Case Western Reserve UniversityORCID 0000-0002-8779-088XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 2 Genomics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:metagenomics· 1

Frequent Co-Authors

Fabio CominelliiD· 3 shared Abigail Raffner BassoniD· 2 shared Carlo De SalvoiD· 2 shared Theresa T. PizarroiD· 2 shared A.C.M. VelooiD· 1 shared Abdullah ÖsmeiD· 1 shared Abhinav P. AcharyaiD· 1 shared Abhirami Suresh· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersMolecular Biology

Fabio CominelliORCID

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Author profile →

4 papers

Recent·Most cited

Mesaconic acid delivery via biomaterials and engineered probiotics to the gut reduces inflammation in Crohn's Diseases mouse models

Huikang Qian, Drishtant Singh, Zixuan Chen, Wenfei Zhao, Bo Zhang, Taravat Knodaei, Abhirami Thumsi, Sanmoy Pathak, Abhirami Suresh, Paola Menghini, Julia Schiek, Viveka Rabara, Carlo De Salvo, Harihara Baskaran, Yuji Aso, , Abhinav P. Acharya

The paper develops two strategies to increase mesaconate levels in the gut to reduce inflammation in Crohn's Disease mouse models.

bioRxiv · Oct 7, 2026 · PreprintImmunology

Epithelial and stromal remodeling in murine Crohn's disease-like ileitis

Katherine C. Letai, Bianca N. Islam, Paola Menghini, Carlo De Salvo, Neha S Khandekar, Bruce W Armstrong, Alka Tomar, Kimberly Curry, Theresa T. Pizarro, Paul J. Tesar, Marissa A. Scavuzzo, Fabio Cominelli

The paper uses snRNA-seq to analyze ileitis in SAMP mice, identifying stromal and epithelial transcriptional changes that mirror human CD, including Igf1 and Pcsk6 expression.

bioRxiv · Nov 8, 2025 · PreprintMolecular Biology

TL1A/DR3 signaling regulates the generation of pathogenic Th9 cells in experimental inflammatory bowel disease

Paola Menghini, Ludovica F. Buttó, Adrian Gomez-Nguyen, Natalia A. Aladyshkina, Kristine-Ann G. Buela, Abdullah Ösme, Ricky Chan, Hannah L. Wargo, Stefania De Santis, Giorgos Bamias, Theresa T. Pizarro, Fabio Cominelli

This study shows that DR3 signaling promotes Th9 cell pathogenicity in CD-like ileitis by enhancing pro-inflammatory signatures and reducing anti-inflammatory responses.

Gastroenterology · May 15, 2025Peer-reviewedImmunology

Clonal Parabacteroides from Gut Microfistulous Tracts as Transmissible Cytotoxic Succinate-Commensal Model of Crohn's Disease Complications

Vaidhvi Singh, Gail A. West, Claudio Fiocchi, Caryn E. Good, Jeffry Katz, Michael R. Jacobs, Armand E. K. Dichosa, Chris A. Flask, Mathew Wesolowski, Cassidy McColl, Brandon J. Grubb, S. Ansar Ahmed, Nicholas C. Bank, Kavitha Thamma, Ilya R. Bederman, , Alexander Rodriguez‐Palacios

The paper identifies clonal Parabacteroides distasonis isolates from CD-associated gut fistulas that exhibit pathogenic traits in mouse models and show potential for transmissibility and adaptation to CD-like ileitis.

bioRxiv · Jan 9, 2024 · PreprintGenomics