ApoE isoforms differentially regulate neuronal membrane proteasomes to shift the threshold for pathological aggregation of endogenous Tau
Victoria Paradise, M Sabu, J Bafia, NA Sharif, C Nguyen, KD Konrad-Vicario, Rijuta D. Mukim, Xudong Wang, BT Corjuc, Jack M. Fu, G Maldonado, J Ndubisi, M Strickland, H Figueroa, D Almeida, , KV Ramachandran
This study shows ApoE isoforms modulate neuroproteasome function, affecting Tau aggregation thresholds and contributing to Alzheimer's disease pathology.
bioRxiv · Nov 29, 2022 · PreprintNeuroscience