Replication stress marker phospho-RPA2 predicts response to platinum and PARP inhibitors in homologous recombination-proficient ovarian cancer
Angela M. Schab, Amanda J. Compadre, Rikki Drexler, Megan Loeb, Kevin Rodriguez, Joshua D. Brill, Shariska Petersen Harrington, Carmen Sandoval, Brooke E. Sanders, Lindsay M. Kuroki, Carolyn Kay McCourt, Andrea R. Hagemann, Premal H. Thaker, David Gardner Mutch, Matthew A. Powell, , Mary Margaret Mullen
This study identifies phospho-RPA2 as a biomarker predicting response to platinum and PARP inhibitors in HR-proficient ovarian cancer, showing higher pathologic complete response and longer survival in pRPA2-High tumors.
Journal of Clinical Investigation · May 20, 2025Peer-reviewedCancer Biology