Analysis of natural structures and chemical mapping data reveals local stability compensation in RNA
Robert Cornwell-Arquitt, Riley Nigh, Michael T Hathaway, Joseph David Yesselman, David A. Hendrix
The paper introduces local stability compensation (LSC) as a principle governing RNA folding, showing it is prevalent in RNA structures and validated through chemical mapping experiments.
Nucleic Acids Research · Jun 12, 2025Peer-reviewedBiophysics