Unconventional secretion of angiogenic sonic-hedgehog-containing large extracellular vesicles is stimulated via the PI3K/Rab18-GDP pathway
Shuo Wang, Rio Imai, Yuya Kaneko, Yosuke Tanaka
The paper shows that PI3K-Rab18-GDP signaling promotes secretion of SHH-containing large extracellular vesicles from hMSCs and fibroblasts, which drive angiogenesis.
Journal of Extracellular Biology · Jan 28, 2026Peer-reviewedCell Biology