Mechanisms of fork stalling and reversal at pathogenic CANVAS (AAGGG)n repeats
Nicolas D. Mandel, Sofia Movafaghi, Rishika Vaid, Olga Usalka, Simone Ummarino, Joe M. Polyak, Masayoshi Honda, N Amir Mozafari, Rula Zain, Maria Spies, Sergei M. Mirkin
This paper investigates how (AAGGG)n repeats in the RFC1 gene cause DNA replication fork stalling and reversal, implicating G4-DNA and SMARCAL1 in the process.
bioRxiv · Oct 30, 2026 · PreprintMolecular Biology