Simone Ummarino

This paper investigates how (AAGGG)n repeats in the RFC1 gene cause DNA replication fork stalling and reversal, implicating G4-DNA and SMARCAL1 in the process.

This study identifies the mechanism by which AW1-51, a small activating RNA, promotes DNA demethylation and reactivation of the CEBPA gene in cancer.

This study identifies a PU.1/LOUP feed-forward regulatory loop that promotes monocyte/macrophage differentiation and innate immune functions through enhancer RNA-mediated mechanisms.

This paper develops an RNA-based aptamer, aptaDiR, that neutralizes DNMT1 function to block DNA methylation and impair cancer cell viability.

This study shows that NAD affects DNA methylation and cell differentiation by promoting ADP-ribosylation of DNMT1, leading to CEBPA activation and myeloid differentiation.

The paper shows that cell cycle-specific long noncoding RNAs regulate the establishment and recycling of the acetylated histone H2A.Z epigenetic mark.

The paper identifies S-phase RNAs that anchor ORC1 to H2A.Z, enabling DNA replication initiation and revealing an RNA-mediated mechanism for replication origin formation.

This study shows that deleting calcineurin in astrocytes impairs neuronal excitability in the cerebellum and hippocampus by reducing Na+/K+-ATPase activity.