Human Sperm-Induced Cell-Cell Fusion Requiring JUNO (hSPICER): A paradigm shift to test sperm fertilizing potential
Nicolás Gastón Brukman, Maharan Kabha, Rivka Levi, Rinad Abbas, Shira Baram, Ronit Beck‐Fruchter, Benjamin Podbilewicz
The paper introduces hSPICER, a functional assay to assess sperm fertilizing potential by measuring cell-cell fusion with hJUNO-expressing cells, showing correlation with in vitro fertilization outcomes.
bioRxiv · May 11, 2026 · PreprintDevelopmental Biology