BioengineeringbioRxivPreprint
Electrostatic-driven Interactions Enhance Intratumoral Retention and Antitumor Efficacy of Immune Checkpoint Blockade Antibodies
Rashmi P Mohanty, Yuting Pan, Mae M Lewis…·Debadyuti Ghosh
Peptide-conjugated immune checkpoint blockade antibodies show enhanced antitumor efficacy through electrostatic interactions with tumor ECM, increasing CD8+ T cell infiltration and reducing regulatory T cells.
DOI 10.1101/2023.12.22.573144