Novel Pan-ALDH Inhibitor KS100 Effectively Targets ALDH+/CD138- Stem-like Cells to Overcome Relapse in Multiple Myeloma
Robert J. Chitren, Krishne Gowda, Shantu Amin, Gavin P. Robertson, Subash C. Jonnalagadda, Tülin Budak-Alpdoǧan, Manoj Kumar Pandey
This study identifies KS100, a pan-ALDH inhibitor, as effective in reducing ALDH expression and viability of multiple myeloma cells, particularly ALDH+/CD138- stem-like cells, potentially overcoming relapse.
bioRxiv · Mar 6, 2025 · PreprintMolecular Biology