A Novel Niclosamide Sulfate Prodrug with Enhanced Bioavailability Suppresses Hepatocellular Carcinoma via Inhibition of Multiple Signaling Pathways
Mingdian Tan, Steve Schow, Yi Liu, Robert Lum, Dawiyat Massoudi, Renumathy Dhanasekaran, Samuel K. So, Mei‐Sze Chua
This paper develops a niclosamide sulfate prodrug, SSL-0024, which improves solubility and bioavailability, showing strong anti-tumor effects against hepatocellular carcinoma through multiple pathway inhibition.
bioRxiv · Apr 15, 2026 · PreprintCancer Biology