Robert Yang

Genetically Proxied Telomere Length but Not Epigenetic Aging Acceleration Causally Influences Healthspan: A Mendelian Randomization Study

This study uses Mendelian randomization to show that genetically predicted longer telomere length causally extends healthspan, but epigenetic age acceleration biomarkers do not.

Genome-wide meta-analysis conducted in three large biobanks expands the genetic landscape of lumbar disc herniations

This study conducts a genome-wide meta-analysis across three biobanks to identify new genetic loci associated with lumbar disc herniation, expanding the known genetic landscape.

MARVEL: Microenvironment Annotation by Supervised Graph Contrastive Learning

MARVEL improves microenvironment annotation by using supervised graph contrastive learning to embed spatial cell relationships into a continuous space, outperforming existing methods in three tasks.

GWAS of preeclampsia and hypertensive disorders of pregnancy uncovers genes related to cardiometabolic, endothelial and placental function

This study conducts a GWAS of preeclampsia and hypertensive disorders of pregnancy, identifying 18 genome-wide significant loci, including novel associations with blood pressure and placental function.

Large-scale Analyses of Disease Biomarkers and Apremilast Pharmacodynamic Effects

The paper identifies disease severity and pharmacodynamic biomarkers in psoriasis and ankylosing spondylitis using plasma proteomic data from apremilast clinical trials.

A systematic survey of human tissue-specific gene expression and splicing reveals new opportunities for therapeutic target identification and evaluation

The paper analyzes tissue-specific gene expression and splicing across 8527 RNA-seq samples to identify therapeutic targets and prioritize disease-associated genes.