Jaakko S. Tyrmi

Disentangling Maternal and Fetal Genetic Contributions to Preeclampsia

This study identifies maternal and fetal genetic contributions to preeclampsia through genome-wide association analyses, revealing distinct genetic architectures and biological pathways.

Optimizing Exome Captures in Species with Large Genomes Using Species-specific Repetitive DNA Blocker

This study evaluates species-specific c0t-1 DNA blockers for exome capture in Pinus sylvestris, showing improved performance over universal blockers.

Genomic and proteomic evidence for hormonal and metabolic foundations of polycystic ovary syndrome

This study identifies 31 plasma proteins and expands genetic loci associated with PCOS, highlighting metabolic and hormonal influences and polygenic risk effects on cardio-metabolic outcomes.

Understanding and Predicting Polycystic Ovary Syndrome through Shared Genetics with Testosterone, SHBG, and Chronic Inflammation

This study identifies genetic loci associated with PCOS and shows genetic correlations with inflammation and sex hormones, improving PCOS prediction through polygenic risk scores.

Pregnancy-Associated Bleeding and Genetics: Five Sequence Variants in the Myometrium and Progesterone Signaling Pathway are associated with postpartum hemorrhage

The paper identifies five genetic loci associated with postpartum hemorrhage through a meta-analysis and links them to progesterone receptor binding sites and related traits.

GWAS of preeclampsia and hypertensive disorders of pregnancy uncovers genes related to cardiometabolic, endothelial and placental function

This study conducts a GWAS of preeclampsia and hypertensive disorders of pregnancy, identifying 18 genome-wide significant loci, including novel associations with blood pressure and placental function.

Taming the massive genome of Scots pine with PiSy50k, a new genotyping array for conifer research

The paper develops a 50K SNP genotyping array for Scots pine to enable genome-wide analyses and improve genetic research and breeding programs.

Leveraging Northern European population history; novel low frequency variants for polycystic ovary syndrome

This study identifies three novel low-frequency variants associated with PCOS using a Finnish-Estonian GWAS, highlighting the value of population-specific genetic analysis.

Evidence of a causal relationship between genetic tendency to gain muscle mass and uterine leiomyomata

This study identifies 36 novel genetic loci associated with uterine leiomyomata and suggests a causal link between genetic predisposition to increased fat-free mass and UL risk.

Genomics of clinal local adaptation in Pinus sylvestris under continuous environmental and spatial genetic setting

This study identifies coding loci and a large inversion associated with local adaptation in Pinus sylvestris using landscape genomics and targeted sequencing.

STAPLER: a simple tool for creating, managing and parallelizing common high-throughput sequencing workflows

STAPLER simplifies creating, managing, and parallelizing bioinformatics workflows with user-friendly tools and modular customization.