Dysfunctional glymphatic system with disrupted aquaporin-4 expression pattern on astrocytes causes bacterial product accumulation in the CSF during pneumococcal meningitis
Jaqueline S. Generoso, Sigrun Thorsdottir, Allan Collodel, Diogo Dominguini, Roberta R. E. Santo, Fabricia Cardoso Petronilho, Tatiana Barichello, Federico Iovino
This study shows pneumococcal meningitis impairs the glymphatic system, leading to bacterial accumulation in CSF and neuronal damage due to AQP4 misplacement.
mBio · Aug 29, 2022Peer-reviewedNeuroscience