The microtubule-binding protein EML3 is required for mammalian embryonic growth and cerebral cortical development; Eml3 null mice are a model of cobblestone brain malformation
Isabelle Carrier, Eduardo Diez, Valerio E. C. Piscopo, Susanne Bechstedt, Hans van Bokhoven, Myriam Srour, Albert Marinus Berghuis, Stefano Stifani, Yojiro Yamanaka, Roderick R. McInnes
This study shows that EML3 is essential for embryonic growth and cortical development, with its absence causing cobblestone brain malformation due to disrupted pial basement membrane structure.
eLife · Jul 9, 2026Peer-reviewedDevelopmental Biology