Valerio E. C. Piscopo

USP15 REGULATES NEUROINFLAMMATION AND DRIVES PATHOGENESIS IN SYNUCLEINOPATHIES

This study shows that USP15 deletion in astrocytes and microglia reduces neuroinflammation and slows synucleinopathy progression in mice, with human data linking USP15 expression to Parkinson's disease risk.

The microtubule-binding protein EML3 is required for mammalian embryonic growth and cerebral cortical development; Eml3 null mice are a model of cobblestone brain malformation

This study shows that EML3 is essential for embryonic growth and cortical development, with its absence causing cobblestone brain malformation due to disrupted pial basement membrane structure.

Single nuclear RNA sequencing shows altered microglial and astrocytic functions in post-mortem Parkinson's disease tissue

This study uses snRNA-seq data from post-mortem Parkinson's disease tissue to identify altered molecular pathways in microglia and astrocytes, showing upregulated protein misfolding responses and downregulated inflammation-related genes.

Microbiota-derived extracellular vesicles link intestinal dysbiosis to neuroimmune activation in long COVID

This study identifies gut microbiota-derived extracellular vesicles as mediators linking intestinal dysbiosis to neuroimmune activation in Long COVID.

Age and maturation stage linked consequences of fibrinogen on human oligodendroglia

This study shows fibrinogen has opposing effects on human oligodendrocyte lineage cells depending on their maturation stage, inhibiting early differentiation but enhancing myelination in mature cells.

A validated antibody toolbox for ALS research

The paper establishes a validated antibody platform for ALS research, identifying high-quality antibodies and revealing protein expression patterns in neurological cell types.

Pro-Inflammatory Molecules Implicated in Multiple Sclerosis Divert the Development of Human Oligodendrocyte Lineage Cells

This study shows that TNF and IFNγ inhibit human OPC differentiation into oligodendrocytes and promote an astrocyte-like reactive phenotype, potentially contributing to impaired myelin repair in MS.

Single Cell RNAseq to identify subpopulations of glial progenitors in iPSC-derived oligodendroglial lineage cultures

The paper uses single-cell RNA sequencing to identify subpopulations of glial progenitors in iPSC-derived oligodendroglial lineage cultures and characterizes their differentiation response.

An adapted stem cell-derived microglia protocol for the study of microgliopathies and other neurological disorders

The paper optimizes an iMGL protocol to generate microglia-like cells from an ALSP patient, revealing functional defects in migration and phagocytosis.

CelltypeR: A flow cytometry pipeline to annotate, characterize and isolate single cells from brain organoids

The paper develops a flow cytometry pipeline called CelltypeR to annotate and characterize cell types in brain organoids, identifying dopamine neuron subtypes and tracking cell type dynamics over time.