Discovery and structure-activity relationship analysis of 2-Pyridyl Thienopyrimidine derivatives as promising therapeutic candidates for the treatment of Buruli ulcer
Rodrigue Keumoe, Rufin Marie Kouipou Toghueo, Eugenie Aimée Madiesse Kemgne, Jean Baptiste Hzounda Fokou, Darline Dize, Patrick Valère Tsouh Fokou, Boniface Pone Kamdem, Adele Honorine Enangue Makembe, Michelle Sidoine Nguembou Njionhou, Atanu Ghoshal, Abhijit Kundu, Benoı̂t Laleu, Fabrice Fekam Boyom
This study identifies new anti-Buruli ulcer compounds from a compound library and evaluates their structure-activity relationships and cytotoxicity.
bioRxiv · May 12, 2025 · PreprintPharmacology & Toxicology