Elucidating the roles of Alzheimer disease-associated proteases and the signal-peptide peptidase-like 3 (SPPL3) in the shedding of glycosyltransferases
Assou El-Battari, Sylvie Mathieu, Romain Sigaud, Maëlle Prorok-Hamon, L’Houcine Ouafik, Charlotte Jeanneau
This study investigates the roles of Alzheimer disease-associated proteases, including SPPL3, in the shedding of glycosyltransferases, finding that SPPL3, but not BACEs or Presenilins, is involved in cleaving and releasing some glycosyltransferases.
bioRxiv · May 8, 2018 · PreprintBiochemistry